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GNRHR Polyclonal Antibody

CAT: 0763-E-AB-12492-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-12492-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH) . Defects in this gene are a cause of hypogonadotropic hypogonadism (HH) . Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Abbreviation
GNRHR
UniProt
P30968
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Synthetic peptide of human GNRHR
Target
GnRH receptor; GnRH-R; GNRHR; GNRHR; GNRHR1; Gonadotropin releasing hormone receptor; gonadotropin-releasing hormone (type 1) receptor 1; Gonadotropin-releasing hormone receptor; GRHR; HH7; leutinizing-releasing hormone receptor; lh-rh; LHRHR; LRHR; luliberin receptor; luteinizing hormone releasing hormone receptor; type I GnRH receptor
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Neuroscience
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
28kDa
Isotype
IgG

UniProtKB · P30968

Gonadotropin-releasing hormone receptor

GNRHR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30968
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GNRHR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GnRH receptor, GnRH-R
EC number
—
Processing
—
Secondary accessions
O75793, Q14D13, Q92644
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

Disease

Disease variantHypogonadotropic hypogonadism

PTM

Disulfide bondGlycoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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