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AIM2 Polyclonal Antibody

CAT: 0763-E-AB-10974-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10974-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-, AIM2 is thought to act as a tumor suppressor by repressing NFB transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of -helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.
Abbreviation
AIM2
UniProt
O14862
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human AIM2
Target
Absent in melanoma 2; AIM 2; Aim2; AIM2; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Affinity purification
Concentration
0.8 mg/mL
Dilution
IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · O14862

Interferon-inducible protein AIM2

AIM2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14862
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AIM2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K7M7, Q5T3V9, Q96FG9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

CytoplasmInflammasomeNucleus

Biological process

DNA damageImmunityInflammatory responseInnate immunity

Molecular function

DNA-binding

Disease

Tumor suppressor

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