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CRTAM Polyclonal Antibody

CAT: 0763-E-AB-10260-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-10260-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The CRTAM gene is upregulated in CD4 (see MIM 186940) -positive and CD8 (see CD8A; MIM 186910) -positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
Abbreviation
CRTAM
UniProt
O95727
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant protein of human CRTAM
Target
CD355; Class I MHC restricted T cell associated molecule; Class-I MHC-restricted T-cell-associated molecule; CRTAM; CRTAM; Cytotoxic and regulatory T cell molecule; Cytotoxic and regulatory T-cell molecule
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Immunology
Purification
Affinity purification
Concentration
0.3 mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
45kDa
Observed Molecular Weight
Refer to Figures
Isotype
IgG

UniProtKB · O95727

Cytotoxic and regulatory T-cell molecule

CRTAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95727
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CRTAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q59EI1, Q6IRX2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityCell adhesionImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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