Elab Fluor® Red 780 Anti-Mouse F4/80 Antibody[CI:A3-1]

• Background:

  F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF) -transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

• Abbreviation:

  F4/80

• Gene ID:

  13733

• UniProt:

  Q61549

• Host:

  Rat

• Reactivity:

  Mouse

• Target:

  Gpf480; Adgre1; Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module receptor 1; Emr1

• Clonality:

  Monoclonal

• Clone:

  CI:A3-1

• Conjugation:

  Elab Fluor®Red 780

• Applications:

  FCM

• Field of Research:

  Cell Biology; Immunology; Innate Immunity; Neuroinflammation; Neuroscience

• Concentration:

  5 μL/Test

• Buffer:

  Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

• Citation 01:

  https://www.sciencedirect.com/science/article/pii/S1742706123003501

• Citation 02:

  https://www.sciencedirect.com/science/article/pii/S014181302301070X

• Citation 03:

  https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00168-8

• Recommended Usage:

  The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

• Isotype:

  Rat IgG2b, κ