Purified Mouse IgG1, κ Isotype Control[MOPC-21]

• Background:

  CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.

• Host:

  Mouse

• Clonality:

  Monoclonal

• Clone:

  MOPC-21

• Conjugation:

  Unconjugated

• Applications:

  FCM

• Concentration:

  ≥ 1 mg/mL

• Buffer:

  Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

• Citation 01:

  https://europepmc.org/article/pmc/pmc8688850?javascript_support=no

• Recommended Usage:

  Each lot of this antibody is quality control tested by flow cytometric analysis as negative control. Use at concentrations comparable to those of the specific antibody of interest.

• Isotype:

  Mouse IgG1, κ