Torin 1

• Description:

  Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  Autophagy; mTOR

• Type:

  Reference compound

• Related Pathways:

  Autophagy; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Torin-1.html

• Purity:

  99.28

• Solubility:

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1N(C2=C(C=C1)C=NC3=CC=C(C=C32)C4=CC5=CC=CC=C5N=C4)C6=CC=C(C(C(F)(F)F)=C6)N7CCN(CC7)C(CC)=O

• Molecular Formula:

  C35H28F3N5O2

• Molecular Weight:

  607.62

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Thoreen CC, et al, An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem, 2009, 284 (12), 8023-8032.|[2]Liu Q, et al. Discovery of 1- (4- (4-propionylpiperazin-1-yl) -3- (trifluoromethyl) phenyl) -9- (quinolin-3-yl) benzo[h][1,6]naphthyridin-2 (1H) -one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 2010 Oct 14;53 (19) :7146-55.|[3]Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102 (4) :755-764.|[4]Brandt M, et al. mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. Cell Metab. 2018 Jan 9;27 (1) :118-135.e8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MTOR; mTORC1; mTORC2

• CAS Number:

  [1222998-36-8]