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Phaseic acid

CAT: 0804-HY-111973-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111973-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC50 of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect[1][2].
CAS Number
24394-14-7
UNSPSC
12352005
Target
IGluR; Phytohormone
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phaseic-acid.html
Purity
98.76
Solubility
10 mM in DMSO
Smiles
O=C(O)/C=C(C)\C=C\[C@]1(O)[C@]2(C)CC(C[C@@]1(C)OC2)=O
Molecular Formula
C15H20O5
Molecular Weight
280.32
References & Citations
[1]Pedro L Rodriguez, et al. Abscisic Acid Catabolism Generates Phaseic Acid, a Molecule Able to Activate a Subset of ABA Receptors. Mol Plant. 2016 Nov 7;9 (11) :1448-1450.|[2]Hou ST, et al., Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 2016 Dec 30;291 (53) :27007-27022.|[3]Sharkey TD, et al., Effects of phaseic Acid and dihydrophaseic Acid on stomata and the photosynthetic apparatus. Plant Physiol. 1980 Feb;65 (2) :291-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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