Phaseic acid

• Description:

  Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC50 of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect[1][2].

• UNSPSC:

  12352005

• Target:

  IGluR; Phytohormone

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/phaseic-acid.html

• Purity:

  98.76

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)/C=C(C)\C=C\[C@]1(O)[C@]2(C)CC(C[C@@]1(C)OC2)=O

• Molecular Formula:

  C15H20O5

• Molecular Weight:

  280.32

• References & Citations:

  [1]Pedro L Rodriguez, et al. Abscisic Acid Catabolism Generates Phaseic Acid, a Molecule Able to Activate a Subset of ABA Receptors. Mol Plant. 2016 Nov 7;9 (11) :1448-1450.|[2]Hou ST, et al., Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 2016 Dec 30;291 (53) :27007-27022.|[3]Sharkey TD, et al., Effects of phaseic Acid and dihydrophaseic Acid on stomata and the photosynthetic apparatus. Plant Physiol. 1980 Feb;65 (2) :291-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [24394-14-7]