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Lithocholic acid

CAT: 0804-HY-B0172-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0172-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist[1][2][3][4][5].
CAS Number
434-13-9
Product Name Alternative
3α-Hydroxy-5β-cholanic acid
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Apoptosis; Autophagy; Endogenous Metabolite; FXR
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Lithocholic-acid.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.99 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)
Smiles
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@]([C@@]4([C@](C[C@H](O)CC4)([H])CC3)C)([H])CC1
Molecular Formula
C24H40O3
Molecular Weight
376.57
Precautions
H315, H319, H335
References & Citations
[1]Jenkins, D.J., et al., Effect on blood lipids of very high intakes of fiber in diets low in saturated fat and cholesterol. N Engl J Med, 1993. 329 (1) : p. 21-6.|[2]Goldberg, A.A., et al., Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget, 2011. 2 (10) : p. 761-82.|[3]Matsubara, T., et al., TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res, 2012. 53 (12) : p. 2698-707.|[4]Yang R, et al. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol. 2018 Jul 14;120:253-260.|[5]Yu J, et al. Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277 (35) :31441-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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