Nudifloramide-d3

• Description:

  Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly (ADP-ribose) polymerase (PARP-1) activity in vitro[1].

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; PARP

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Purity:

  99.47

• Solubility:

  10 mM in DMSO|H2O : 33.33mg/mL (ultrasonic)

• Smiles:

  C(N)(=O)C1=CN(C([2H])([2H])[2H])C(=O)C=C1

• Molecular Formula:

  C7H5D3N2O2

• Molecular Weight:

  155.17

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Rutkowski B, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl. 2003 May; (84) :S19-21.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1207384-48-2]