KRASG12D-IN-3

• UNSPSC Description:

  KRASG12D-IN-3 (compound Z1084) is an orally active KRASG12D inhibitor that inhibits the cell growth of AGS and AsPC-1 cells with IC50 values of 0.38 nM and 1.23 nM, respectively[1].

• Target Antigen:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/krasg12d-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(C(F)(F)F)C(C2=C(F)C(N=C(OC[C@]3(C/C(C4)=C(F)\F)N4CCC3)N=C5N(C[C@@H]6N[C@H]7CC6)[C@@H]7[C@H](C)O8)=C5C8=N2)=CC(N)=C1

• Molecular Weight:

  682.06

• References & Citations:

  [1]Tao Jiang, et al. Pyrimidine-fused ring compound, and preparation method therefor and use thereof. WO2024061370A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3033638-63-7