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PVZB1194

CAT: 0804-HY-122247-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122247-01Size:10 mg
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Description
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM) . PVZB1194 can be used in the study of tumors[1][2].
CAS Number
1141768-04-8
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pvzb1194.html
Purity
99.64
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
Molecular Formula
C13H9F4NO2S
Molecular Weight
319.27
References & Citations
[1]Sawada JI, et al. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021 Nov;193:114789.|[2]Matsuno K, et al. Bis (hetero) aryl derivatives as unique kinesin spindle protein inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19 (4) :1058-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-5/Eg5/KSP

Chemical Information

3'-Fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide
CAS Number1141768-04-8
PubChem CID44590437
IUPAC Name4-[3-fluoro-4-(trifluoromethyl)phenyl]benzenesulfonamide
Molecular FormulaC13H9F4NO2S
Molecular Weight319.28
XLogP3.1
Topological Polar Surface Area68.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity452
SMILES
C1=CC(=CC=C1C2=CC(=C(C=C2)C(F)(F)F)F)S(=O)(=O)N
InChI
InChI=1S/C13H9F4NO2S/c14-12-7-9(3-6-11(12)13(15,16)17)8-1-4-10(5-2-8)21(18,19)20/h1-7H,(H2,18,19,20)
InChIKey
UEPKMFLFRNDVAW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3'-Fluoro-4'-(trifluoromethyl)biphenyl-4-sulfonamide
CAS: 1141768-04-8
CID: 44590437
Formula: C13H9F4NO2S
MW: 319.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight319.28
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass319.02901235
Monoisotopic Mass319.02901235
Topological Polar Surface Area68.5 Ų
Heavy Atom Count21
Formal Charge0
Complexity452
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4223-50PVZB1194

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