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RecombinantBMP-3B, Human

CAT: 0013-GTR18991968-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18991968-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bone Morphogenetic Protein-3B (BMP-3B), also known as Growth/Differentiation Factor 10 (GDF-10), is a cytokine belonging to the Transforming Growth Factor β (TGF-β) superfamily. BMP-3B contains the cystine knot motif shared by other TGF-β family members. BMP-3B was originally identified by PCR based on the BMP-3 sequence, and shares 83% identity with BMP-3. BMP-3B and BMP-2 act as mutual antagonists, as they compete for the availability of signaling protein Smad4. In vivo, BMP-3B is highly expressed in brain, lungs, and bone tissues. The functions of BMP-3B include acting as a dorsaling factor in head development, inhibition of adipogenesis in adipocytes, and induction of bone formation. BMP-3B is down-regulated in lung cancer patient samples, indicating its potential antitumor activity. Recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) produced in E.coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 111 amino acids each. rhBMP-3B has a molecular mass of 25.1 kDa analyzed by non-reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
Osteogenin, BMP-3A, BMP3B, BMP3A
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE and HPLC.
Form
Lyophilized after extensive dialysis against 4mM HCl.
Molecular Weight
25.1 kDa, observed by non-reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhBMP-3B remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in 4mM HCl at 100 μg/mL.
Preservative
Lyophilized after extensive dialysis against 4mM HCl.
AA Sequence
MQWDEPRVC SRRYLKVDFA DIGWNEWIIS PKSFDAYYCA GACEFPMPKI VRPSNHATIQ SIVRAVGIIP GIPEPCCVPD KMNSLGVLFL DENRNVVLKV YPNMSVDTCA CR

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