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RecombinantFGF-18, Human

CAT: 0013-GTR18991769-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18991769-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fibroblast Growth Factor-18 (FGF-18) is a heparin-binding growth factor that is a member of the FGF family. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. FGF-18 plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. FGF-18 is required for normal ossification and bone development. It can also stimulate hepatic and intestinal proliferation.Recombinant human Fibroblast Growth Factor-18 (rhFGF-18) produced in E.coli is a single non-glycosylated polypeptide chain containing 174 amino acids. A fully biologically active molecule, rhFGF-18 has a molecular mass of 20.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
FGF18, Fibroblast Growth Factor-18, zFGF5, FGFI
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE and HPLC analyses.
Bioactivity
ED50 1.0x 10ˆ5units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
20.3 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Fibroblast Growth Factor-18 (rhFGF-18) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-18 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
MAEENVDFR IHVENQTRAR DDVSRKQLRL YQLYSRTSGK HIQVLGRRIS ARGEDGDKYA QLLVETDTFG SQVRIKGKET EFYLCMNRKG KLVGKPDGTS KECVFIEKVL ENNYTALMSA KYSGWYVGFT KKGRPRKGPK TRENQQDVHF MKRYPKGQPE LQKPFKYTTV TKRSR

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