Products for Research Use Only
RegisterLogin

RecombinantHB-EGF, Human

CAT: 0013-GTR18990542-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18990542-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds to the EGF receptor with a higher affinity and has been shown to bemore mitogenic, likely due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has also been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin. Heparin-binding EGF-like growth factor has been shown to interact with NRD1, Zinc finger and BTB domain-containing protein 16 and BAG1.Recombinant Human HB-EGF produced in E.coli cells is a polypeptide chain containing 86 amino acids. A fully biologically active molecule, rhHB-EGF has a molecular mass of 14 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Product Name Alternative
DTR, DTS, HEGFL
Source
Escherichia coli.
Field of Research
Cancer Biology
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50 < 0.75ng/ml, measured in a cell proliferation assay using 3T3 cells.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
14 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant Human Proheparin-binding EGF-like Growth Factor (HB-EGF), remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human HB-EGF should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O or PBS at 100 μg/ml.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
GD LQEADLDLLR VTLSSKPQAL ATPNKEEHGK RKKKGKGLGK KRDPCLRKYK DFCIHGECKY VKELRAPSCI CHPGYHGERC HGLSL

Related Products

CatalogName
GTR18878415Human EGF Recombinant
GTR19126142-01Recombinant Human EGF Protein
GTR18903271-01Human EGF protein
GTR19145129-01Human EGF protein
GTR18985768-01Human EGF Protein
GTR19337773-01EGF siRNA (Human)
GTR19144909Human EGF protein
GTR18888392-01Human EGF protein
GTR19068999Human EGF Protein
GTR18906282-01Human EGF protein

Alternative Products

CatalogName
BK0218-01RecombinantHB-EGF, Human
BK0218RecombinantHB-EGF,Human
Z02691-100EGF, Human
300-110P-5mgHuman EGF
CYT-217-01EGF Human
PGR-4498-SEGF (Human)
4030572.05rec EGF (human)

Popular Products