Products for Research Use Only
RegisterLogin

RecombinantLIF, Human

CAT: 0013-GTR18990493-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18990493-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine belonging to the long four-helix bundle cytokine superfamily. LIF shares tertiary structure with several other cytokines, including Interleukin-6 (IL-6), Oncostatin M, ciliary neurotropic factor, and cardiotrophin-1, and their functions in vivo are also redundant to some extent. LIF can bind to the common receptor of IL-6 subfamily, gp130, and then recruit its own receptor LIF Receptor to form a ternary complex. The basal expression of LIF in vivo is low; and its expression is induced by pro-inflammatory factors, including lipopolysaccharide, IL-1, and IL-17, and inhibited by anti-inflammatory agents, including IL-4 and IL-13. The functions of LIF include proliferation of primordial germ cells, regulation in blastocyst implantation and early pregnancy, and maintenance of pluripotent embryonic stem cells.Recombinant human Leukemia Inhibitory Factor (rhLIF) produced in E.coli is a single non-glycosylated polypeptide chain containing 180 amino acids. A fully biologically active molecule, rhLIF has a molecular mass of 19.7 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Product Name Alternative
D factor, MLPLI
Source
Escherichia coli.
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE analysis.
Bioactivity
ED50 5 x 10ˆ6 units/mg.
Form
Lyophilized after extensive dialysis against PBS.
Molecular Weight
19.7 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Leukemia Inhibitory Factor (rhLIF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhLIF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Notes
For research use only.
Applications Notes
Reconstituted in ddH2O at 100 μg/mL.
Preservative
Lyophilized after extensive dialysis against PBS.
AA Sequence
SPL PITPVNATCA IRHPCHNNLM NQIRSQLAQL NGSANALFIL YYTAQGEPFP NNLDKLCGPN VTDFPPFHAN GTEKAKLVEL YRIVVYLGTS LGNITRDQKI LNPSALSLHS KLNATADILR GLLSNVLCRL CSKYHVGHVD VTYGPDTSGK DVFQKKKLGC QLLGKYKQII AVLAQAF

Related Products

CatalogName
GTR18990492-01RecombinantLIF, Mouse
GTR18990484-01RecombinantMIF, Human
GTR18991891-01RecombinantEGF, Human
GTR18991545-01RecombinantGMF-β, Human
GTR18990453-01RecombinantTNF-α, Human
GTR18990322-01RecombinantHGF, Human
GTR18991880-01RecombinantEGF, Human
GTR18990536-01RecombinantIFN-γ, Human
GTR18990254-01RecombinantTGF-α, Human
GTR18990236-01RecombinantIFN-β, Human

Alternative Products

CatalogName
BK0121RecombinantLIF,Human
BK0121-01RecombinantLIF, Human
BK0122RecombinantLIF,Mouse
BK0122-01RecombinantLIF, Mouse
P83251PMG36e-ADH1B (human-opt-human) -ALDH2 (human-opt-human)
P81559PCMV-Twinstrep-UFM1 (human) -UFM1 (human-opt-human) -UFM1 (human-opt-human) -Neo
P1493-200Human CellExp™ Human Serum Albumin, Human Recombinant
9230-10Human CellExp™ Human CD40/ TNFRSF5, Human recombinant
PT_75080-01Adiponectin Human (Acrp30 Human)
PT_42362-01Urokinase Human (Urokinase Human)

Popular Products