TP63 antibody

CAT: 0710-FNab10723Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab10723Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

TP63, also named KET, P63, P73H, P73L and TP73L, belongs to the p53 family. It is a homologue of the tumor suppressor p53 and p73 genes. It is involved in malignancy acquisition and maintenance of cells. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent abilities to transactivate p53 reporter genes and induce apoptosis. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 has 12 isoforms with MW 40kd (P40), 50kd (P60),63kd (P63) and 73kd (P73L) . It is Nuclear stain.

Synonyms

Tumor protein 63 (p63) |Chronic ulcerative stomatitis protein (CUSP) |Keratinocyte transcription factor KET|Transformation-related protein 63 (TP63) |Tumor protein p73-like (p73L) |p40|p51|TP63|KET|P63|P73H|P73L|TP73L

UniProt

Q9H3D4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Tumor protein p63

Target

TP63

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB,IHC

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IHC: 1:50-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

45-75 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC

Immunogen Sequence

1-200aa

UniProtKB · Q9H3D4

Tumor protein 63

P63_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9H3D4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TP63
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: p63
EC number: —
Processing: —
Secondary accessions: O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative promoter usageAlternative splicing

Biological process

ApoptosisNotch signaling pathwayTranscriptionTranscription regulation

Disease

Disease variantEctodermal dysplasiaPremature ovarian failure

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

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