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P8RI

CAT: 0804-HY-P3325-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3325-02Size:10 mg
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Description
P8RI (D-P8RI) is a biomimetic peptide of CD31 and a CD31 agonist. P8RI binds to the juxtamembrane amino acid sequence of the ectodomain of CD31, shows an immunosuppressive effect through restoration of the CD31 inhibitory pathway[1][2].
CAS Number
2147724-76-1
Product Name Alternative
D-P8RI
UNSPSC
12352209
Target
VEGFR
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p8ri.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL
Smiles
O=C(N1[C@H](CCC1)C(N[C@H](C)C(N[C@H](CC(C)C)C(N[C@@H](C(N[C@H](C(C)C)C(N[C@@H](C(O)=O)CCCNC(N)=N)=O)=O)CC2=CC=CC=C2)=O)=O)=O)[C@H](NC([C@H](N)CCCCN)=O)CC3=CNC4=CC=CC=C34
Molecular Formula
C51H77N13O9
Molecular Weight
1016.24
References & Citations
[1]Diaz-Rodriguez S, et al. Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo. Eur Heart J. 2021;42 (18) :1760-1769. |[2]Sannier A, et al. A CD31-Derived Peptide Prevents the Development of Antibody-Mediated Lesions in a Rat Model of Aortic Allograft. Transplant Proc. 2021;53 (2) :746-749. |[3]Andreata F, et al. Macrophage CD31 Signaling in Dissecting Aortic Aneurysm. J Am Coll Cardiol. 2018;72 (1) :45-57.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

CID 162678845
CAS Number2147724-76-1
PubChem CID162678845
IUPAC Name(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-1-[(2R)-2-[[(2R)-2,6-diaminohexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular FormulaC51H77N13O9
Molecular Weight1016.2
XLogP-0.7
Topological Polar Surface Area364
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count12
Rotatable Bond Count29
Heavy Atom Count73
Formal Charge0
Complexity1880
SMILES
C[C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@@H](CCCCN)N
InChI
InChI=1S/C51H77N13O9/c1-29(2)25-38(45(67)61-39(26-32-15-7-6-8-16-32)46(68)63-42(30(3)4)48(70)59-37(50(72)73)20-13-23-56-51(54)55)60-43(65)31(5)58-47(69)41-21-14-24-64(41)49(71)40(62-44(66)35(53)18-11-12-22-52)27-33-28-57-36-19-10-9-17-34(33)36/h6-10,15-17,19,28-31,35,37-42,57H,11-14,18,20-27,52-53H2,1-5H3,(H,58,69)(H,59,70)(H,60,65)(H,61,67)(H,62,66)(H,63,68)(H,72,73)(H4,54,55,56)/t31-,35-,37-,38-,39-,40-,41-,42-/m1/s1
InChIKey
LXYOOXZYRDPHLW-PJJIIYKISA-N
Chemical Structure
2D Structure
2D structure of CID 162678845
CAS: 2147724-76-1
CID: 162678845
Formula: C51H77N13O9
MW: 1016.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1016.2
XLogP3-0.7
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count12
Rotatable Bond Count29
Exact Mass1015.59672108
Monoisotopic Mass1015.59672108
Topological Polar Surface Area364 Ų
Heavy Atom Count73
Formal Charge0
Complexity1880
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19029937-01P8RI
T39615L-01P8RI acetate

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