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Zagociguat

CAT: 0804-HY-145607-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145607-01Size:5 mg
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Description
Zagociguat (CY-6463) is an orally active and BBB-permeable soluble guanylate cyclase (sGC) stimulator. Zagociguat can increase cGMP levels, regulate blood pressure, improve neuronal function, reduce inflammatory responses, and exert neuroprotective and cognitive-improving effects. Zagociguat can be used in the research of neurodegenerative diseases[1][2].
CAS Number
2201048-82-8
Product Name Alternative
CY-6463; IW-6463
UNSPSC
12352005
Target
Guanylate Cyclase; Interleukin Related
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/zagociguat.html
Purity
99.09
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC1=C(CC2=NC(C3=NN=C(C(F)(F)F)N3)=CN4C=CN=C24)C=CC=C1
Molecular Formula
C16H10F4N6
Molecular Weight
362.28
References & Citations
[1]Debra J. Wallace, et al. Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases. Org Process Res Dev. 2021;25 (10) :2288-2299.|[2]Correia SS, et al. The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases. Front Pharmacol. 2021 May 24;12:656561.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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