MCC950

• Description:

  MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.

• Product Name Alternative:

  CP-456773; CRID3

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  NOD-like Receptor (NLR)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/MCC950.html

• Concentration:

  10mM

• Purity:

  99.78

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : 9.52 mg/mL (ultrasonic; adjust pH to 10 with 1 M NaOH)

• Smiles:

  O=S(C1=CC(C(C)(O)C)=CO1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O

• Molecular Formula:

  C20H24N2O5S

• Molecular Weight:

  404.48

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21 (3) :248-55.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NLRP3

• Citation 01:

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• CAS Number:

  [210826-40-7]