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Nelonemdaz

CAT: 0804-HY-106408-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-106408-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA) . Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death[1][2].
CAS Number
640290-67-1
Product Name Alternative
Salfaprodil (free base) ; Neu2000
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Neu2000.html
Purity
99.84
Solubility
DMSO : ≥ 112.5 mg/mL
Smiles
OC(C1=C(O)C=CC(NCC2=C(C(F)=C(C(F)(F)F)C(F)=C2F)F)=C1)=O
Molecular Formula
C15H8F7NO3
Molecular Weight
383.22
References & Citations
[1]Gwag BJ, et al. Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine. J Cereb Blood Flow Metab. 2007 Jun;27 (6) :1142-51.|[2]Sung IC, et, al. Neu2000, an NR2B-selective, Moderate NMDA Receptor Antagonist and Potent Spin Trapping Molecule for Stroke. Drug News Perspect. 2010 Nov; 23 (9) : 549-56.|[3]Nishant PV, et, al. Antioxidant Properties of Neu2000 on Mitochondrial Free Radicals and Oxidative Damage. Toxicol In Vitro. 2013 Mar; 27 (2) : 788-97.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor

Alternative Products

CatalogName
M33440-01Nelonemdaz
T41058Nelonemdaz potassium
GTR19212235-01Nelonemdaz Na

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