L-838417

CAT: 0804-HY-W009009-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-W009009-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2[1].

CAS Number

286456-42-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-838417.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN1N=CN=C1COC2=NN3C(C=C2C(C)(C)C)=NN=C3C4=CC(F)=CC=C4F

Molecular Formula

C19H19F2N7O

Molecular Weight

399.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Ciara McCabe, et al. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behavior. Neuropharmacology. 2004 Feb;46 (2) :171-8.|[2]Melissa Morales, et al. Anxiolytic effects of the GABAA receptor partial agonist, L-838,417: Impact of age, test context familiarity, and stress. Pharmacol Biochem Behav. 2013 Aug;109:31-7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-1,2,4-triazolo(4,3-b)pyridazine

CAS Number	286456-42-6
PubChem CID	9908880
IUPAC Name	7-tert-butyl-3-(2,5-difluorophenyl)-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
Molecular Formula	C19H19F2N7O
Molecular Weight	399.4
XLogP	3.2
Topological Polar Surface Area	83
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Heavy Atom Count	29
Formal Charge	0
Complexity	565

SMILES

CC(C)(C)C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F

InChI

InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3

InChIKey

BQDUNOMMYOKHEP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 286456-42-6

CID: 9908880

Formula: C19H19F2N7O

MW: 399.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	399.4
XLogP3	3.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	399.16191458
Monoisotopic Mass	399.16191458
Topological Polar Surface Area	83 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	565
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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TRC-L838417-50MG	L-838417
FD24821-01	L 838417
T22301-01	L-838417 D9
CCP1053-01	A-L-A-L
453434-01	L-Seryl-L-threonyl-L-glycyl-L-isoleucyl-L-seryl-L-valyl-L-prolyl-L-glycyl-L-prolyl-L-methionyl-L-glycyl-L-prolyl-L-seryl-L-glycyl-L-prolyl-L-Arginine
453309-01	L-Glycyl-L-lysyl-L-leucyl-L-isoleucyl-L-tyrosyl-L-seryl-L-alanyl-L-seryl-L-phenylalanyl-L-leucyl-L-tyrosyl-L-seryl-L-glycyl-L-valyl-L-prolyl-L-seryl-L-arganine
453216-01	L-Arginyl-L-valyl-L-α-aspartyl-L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine
JH918176	L-Arginine, L-valyl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginylglycylglycyl-L-arginyl-L-arginyl-L-arginyl-

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