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Oblimersen (sodium)

CAT: 0804-HY-118874A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118874A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oblimersen sodium is a BCL-2 inhibitor targeting BCL-2 RNA. Oblimersen sodium specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen sodium can be used for cancer research[1][2][3].
UNSPSC
12352208
Target
Apoptosis; Bcl-2 Family
Type
Oligonucleotides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oblimersen-sodium.html
Purity
98.09
Solubility
10 mM in H2O
Smiles
[Oblimersen(sodium)]
Molecular Formula
C172H204N62Na17O91P17S17
Molecular Weight
5684.61 (free acid)
References & Citations
[1]Loriot Y, et, al. Inhibition of BCL-2 in small cell lung cancer cell lines with oblimersen, an antisense BCL-2 oligodeoxynucleotide (ODN) : in vitro and in vivo enhancement of radiation response. Anticancer Res. 2010 Oct;30 (10) :3869-78.|[2]Hu Y, et, al. Antitumor efficacy of oblimersen Bcl-2 antisense oligonucleotide alone and in combination with vinorelbine in xenograft models of human non-small cell lung cancer. Clin Cancer Res. 2004 Nov 15;10 (22) :7662-70.|[3]Klasa RJ, et, al. Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment. Antisense Nucleic Acid Drug Dev. 2002 Jun;12 (3) :193-213.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3

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