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Demethoxyfumitremorgin C

CAT: 0804-HY-N7569Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N7569Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage[1].
CAS Number
111768-16-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Caspase; PPAR
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/demethoxyfumitremorgin-c.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C\[C@@H]1N(C([C@@]2([H])N3CCC2)=O)[C@@](C3=O)([H])CC4=C1NC5=CC=CC=C45
Molecular Formula
C21H23N3O2
Molecular Weight
349.43
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kim YS, et al. Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells. Chem Biol Interact. 2017 May 1;269:18-24.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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