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SP27

CAT: 0804-HY-149324-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-149324-01Size:5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SP27 is a PROTAC that can selective degrades PLK4, with a DC50 of 19.5 nM. SP27 can be used for the research of breast cancer[1].
CAS Number
[3034805-75-6]
UNSPSC
12352005
Target
Polo-like Kinase (PLK) ; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sp27.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C(F)=C1)CNC2=NC3=C(C=NN3C4CCN(CC4)C(C5CCN(CC5)C6=CC7=C(C=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=O)C(NC9=NNC(C)=C9)=N2
Molecular Formula
C40H40F2N12O5
Molecular Weight
806.82
References & Citations
[1]Sun Y, et, al. Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer. J Med Chem. 2023 Jun 22;66 (12) :8200-8221.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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