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Nourseothricin (sulfate)

CAT: 0804-HY-129065-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129065-01Size:5 mg
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Description
Nourseothricin sulfate (Streptothricin sulfate) is a broad-spectrum antibiotic that destroys the outer membrane of Gram-negative bacteria and is a dominant selective marker for Fonsecaea pedrosoi[1][2]. Nourseothricin sulfate inhibits protein biosynthesis in prokaryotic cells and strongly inhibits the growth of eukaryotes like fungi and can also be used as a elective marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells[3].
CAS Number
96736-11-7
Product Name Alternative
Streptothricin (sulfate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nourseothricin-sulfate.html
Purity
99.9
Solubility
H2O : ≥ 100 mg/mL
Smiles
NC(O[C@H]1[C@@H](CO)O[C@@H](NC(N2)=N[C@]([C@@]2([H])[C@H](O)CN3)([H])C3=O)[C@H](NC(C[C@@H](N)CCCN(C(C[C@@H](N)CCCNC(C[C@@H](N)CCCN)=O)=O)[H])=O)[C@@H]1O)=O.O=S(O)(O)=O.NC(O[C@H]4[C@@H](CO)O[C@@H](NC(N5)=N[C@]([C@@]5([H])[C@H](O)CN6)([H])C6=O)[C@H](NC(C[C@@H](N)CCCN)=O)[C@@H]4O)=O
Molecular Formula
C50H94N20O22S
Molecular Weight
1359.47
Precautions
H302, H315, H319, H335
References & Citations
[1] Seltmann G. et al. Resistance of Escherichia coli to nourseothricin (streptothricin) : sensitization of resistant strains by abolition of its outer membrane resistance. Zentralbl Bakteriol. 1992 Jan;276 (2) :143-51.|[2]Florencio CS, et al. Genetic manipulation of Fonsecaea pedrosoi using particles bombardment and Agrobacterium mediated transformation. Microbiol Res. 2018 Mar;207:269-279.|[3]Bräunlich H, et al. Renal handling of nourseothricin. Pharmazie. 1988 Mar;43 (3) :200-2.|[4]Suárez-Moreno ZR, et al. Plant-Growth Promotion and Biocontrol Properties of Three Streptomyces spp. Isolates to Control Bacterial Rice Pathogens.. Front Microbiol. 2019 Feb 25;10:290.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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