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Trichlormethiazide

CAT: 0804-HY-B0235-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0235-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].
CAS Number
133-67-5
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Trichlormethiazide.html
Purity
98.54
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O
Molecular Formula
C8H8Cl3N3O4S2
Molecular Weight
380.66
Precautions
H317, H334
References & Citations
[1]K Yao, et al. Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. Jpn J Pharmacol. 1994 Apr;64 (4) :281-8.|[2]J R Ballew, et al. Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension. J Hypertens. 2001 Sep;19 (9) :1601-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched

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