TWEAK/TNFSF12, Human (CHO)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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CAT:

804-HY-P7309-03

Size:

50 µg

Price:

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For price, please contact [email protected].

TWEAK/TNFSF12, Human (CHO)

UNSPSC Description: TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. Human TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (22-42 a.a.). TWEAK/TNFSF12 Protein, Human (CHO) is the extracellular part (R99-H249) of TWEAK protein, produced by CHO cells with tag free.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/tweak-protein-human-cho.html
Purity: 97.00
Smiles: RKTRARRAIA AHYEVHPRPG QDGAQAGVDG TVSGWEEARI NSSSPLRYNR QIGEFIVTRA GLYYLYCQVH FDEGKAVYLK LDLLVDGVLA LRCLEEFSAT AASSLGPQLR LCQVSGLLAL RPGSSLRIRT LPWAHLKAAP FLTYFGLFQV H
Molecular Weight: Approximately 20-22 kDa
References & Citations: [1]Maecker H, et al. TWEAK attenuates the transition from innate to adaptive immunity. Cell. 2005 Dec 2;123(5):931-44.|[2]TNFSF12 TNF superfamily member 12 [Homo sapiens (human)]|[3]Wiley SR, et al. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):241-9.|[4]Lammens A, et al. Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding. PLoS One. 2013 May 8;8(5):e62697.|[5]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.|[6]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.
Shipping Conditions: Blue Ice
Storage Conditions: Stored at -20°C for 2 years

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Cat	Name
HY-P7309-03	TWEAK/TNFSF12, Human (CHO)
HY-P7309-02	TWEAK/TNFSF12, Human (CHO)
HY-P7309-01	TWEAK/TNFSF12, Human (CHO)
HY-P701045-02	TWEAK/TNFSF12, Human (HEK293, hFc)
HY-P701045-01	TWEAK/TNFSF12, Human (HEK293, hFc)
HY-P700156AF-03	Animal-Free TWEAK/TNFSF12, Human (His)
HY-P77263-01	TWEAK/TNFSF12, Human/Cynomolgus (HEK293, Fc)
HY-P77263-02	TWEAK/TNFSF12, Human/Cynomolgus (HEK293, Fc)
HY-P77263-03	TWEAK/TNFSF12, Human/Cynomolgus (HEK293, Fc)
HY-P700156AF-01	Animal-Free TWEAK/TNFSF12, Human (His)