CMB-087229

• Description :

  CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  SOD

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cmb-087229.html

• Purity :

  98.05

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1C=C(COC2=CC(Cl)=CC(Cl)=C2)NN1

• Molecular Formula :

  C10H8Cl2N2O2

• Molecular Weight :

  259.09

• Precautions :

  H315, H319

• References & Citations :

  [1]Tian Chen, et al. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis.J. Med. Chem. 2012, 55, 1, 515–527.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1227692-67-2]