Anti-NIPA (S350) ZC3HC1 Antibody

• Description:

  Boster Bio Anti-NIPA (S350) ZC3HC1 Antibody catalog # A07135S350. Tested in WB, IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1; ZC3HC1; NIPA; HSPC216;

• Gene Name:

  ZC3HC1

• UniProt:

  Q86WB0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthetic peptide, corresponding to amino acids 318-372 of Human NIPA.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Widely expressed. Highly expressed in heart, skeletal muscle and testis. Expressed in brain, placenta, lung, kidney, liver, pancreas, spleen, thymus, prostate, ovary small intestine and colon. Weakly or not expressed in leukocytes.

• Applications:

  WB, IF

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Essential component of a SCF-type E3 ligase complex, SCF (NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1) . Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF (NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.

• Molecular Weight:

  55262 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Nuclear-interacting partner of ALK

• Subcellular Location:

  Nucleus

• Protein Name:

  Nuclear-interacting partner of ALK