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Anti-CHMP1B Antibody

CAT: 0519-A07069Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A07069Size:100 µL
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Description
Boster Bio Anti-CHMP1B Antibody catalog # A07069. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Charged multivesicular body protein 1b; CHMP1.5; Chromatin-modifying protein 1b; CHMP1b; Vacuolar protein sorting-associated protein 46-2; Vps46-2; hVps46-2; CHMP1B; C18orf2;
Gene Name
CHMP1B
UniProt
Q7LBR1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CHMP1B (NP_065145.2) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I, -II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) . ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.
Molecular Weight
22109 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Charged multivesicular body protein 1b
Subcellular Location
Cytoplasm, cytosol. Endosome. Late endosome membrane ; Peripheral membrane protein . Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
Protein Name
Charged multivesicular body protein 1b

UniProtKB · Q7LBR1

Charged multivesicular body protein 1b

CHM1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7LBR1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHMP1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q96E89, Q9HD41
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell cycleCell divisionProtein transportTransport

Domain

Coiled coil

Cellular component

CytoplasmEndosomeMembrane

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