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Anti-IL18RAP Antibody

CAT: 0519-A06457-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A06457-1Size:100 µL
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Description
Boster Bio Anti-IL18RAP Antibody catalog # A06457-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Interleukin-18 receptor accessory protein; IL-18 receptor accessory protein; IL-18RAcP; Accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like
Gene Name
IL18RAP
UniProt
O95256
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human IL18RAP.
Clonality
Polyclonal
Tissue Specificity
Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836) . Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649) . Specifically coexpressed with IL18R1 in T-helper 1 (Th1) cells (PubMed:10925275, PubMed:11046021, PubMed:10653850) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532) . May play a role in IL18- mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable) .
Molecular Weight
68310 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Interleukin-18 receptor accessory protein
Subcellular Location
Cell membrane
Protein Name
Interleukin-18 receptor accessory protein

UniProtKB · O95256

Interleukin-18 receptor accessory protein

I18RA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95256
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL18RAP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-18 receptor accessory protein, IL-18RAcP
EC number
3.2.2.6
Processing
Precursor
Secondary accessions
B2RPJ3, Q2QDE5, Q3KPE7, Q3KPE8, Q53TT4, Q53TU5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

HydrolaseReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Biological process

Inflammatory response

Ligand

NAD

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