Anti-Methylosome subunit pICln CLNS1A Antibody

• Description:

  Boster Bio Anti-Methylosome subunit pICln CLNS1A Antibody catalog # A06086-1. Tested in WB, IHC applications. This antibody reacts with Human.

• Synonyms:

  Methylosome subunit pICln; Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I (Cln) ; Chloride ion current inducer protein; ClCI; Reticulocyte pICln; CLNS1A; CLCI, ICLN;

• Gene Name:

  CLNS1A

• UniProt:

  P54105

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein of human CLNS1A (NP_001284.1) .

• Clonality:

  Polyclonal

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161) . Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

• Molecular Weight:

  26215 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Methylosome subunit pICln

• Subcellular Location:

  Cytoplasm, cytosol

• Protein Name:

  Methylosome subunit pICln