Products for Research Use Only
RegisterLogin

Anti-CBLC Antibody

CAT: 0519-A03693-1Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0519-A03693-1Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Boster Bio Anti-CBLC Antibody catalog # A03693-1. Tested in WB, IF applications. This antibody reacts with Human, Mouse.
Synonyms
E3 ubiquitin-protein ligase CBL-C;2.3.2.27
Gene Name
CBLC
UniProt
Q9ULV8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human CBLC.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous.
Applications
WB, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Molecular Weight
52456 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
E3 ubiquitin-protein ligase CBL-C
Protein Name
E3 ubiquitin-protein ligase CBL-C

UniProtKB · Q9ULV8

E3 ubiquitin-protein ligase CBL-C

CBLC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9ULV8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CBLC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
Q8N1E5, Q9Y5Z2, Q9Y5Z3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Domain

RepeatSH3-bindingZinc-finger

Molecular function

Transferase

Biological process

Ubl conjugation pathway

Related Products

CatalogName
M03693Anti-Cbl c (CBLC) Mouse Monoclonal Antibody [Clone ID: OTI4E3]
PROTQ9ULV8Cbl c (CBLC) (NM_012116) Human Recombinant Protein
LS023624-20ugCbl c (CBLC) (NM_012116) Human Over-expression Lysate
LS023624-100ugCbl c (CBLC) (NM_012116) Human Over-expression Lysate
LS023624Cbl c (CBLC) (NM_012116) Human Over-expression Lysate
A00735-1Anti-CBLB Antibody
A00735Anti-CBLB Antibody
A00152Anti-Cbl Antibody
M00152-1-50ulAnti-CBL Antibody
M00152-1-01Anti-CBL Antibody

Alternative Products

CatalogName
PAab01319Anti-CBLC antibody
A71749-100ULCBLC Antibody

Popular Products