Anti-CBL Antibody

CAT: 0519-M00152-1-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0519-M00152-1-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.

Description

Boster Bio Anti-CBL Antibody (Catalog # M00152-1) . Tested in WB application (s) . This antibody reacts with Human.

Synonyms

E3 ubiquitin-protein ligase CBL, 6.3.2.-, Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, RING finger protein 55, Signal transduction protein CBL, CBL, CBL2, RNF55

Gene Name

CBL

UniProt

P22681

Host

Mouse

Reactivity

Human

Immunogen

This CBL antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 450-644 amino acids from human CBL.

Clonality

Monoclonal

Clone

Clone: 1762CT401.80.60

Applications

Field of Research

Cancer, Cell Biology, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Dilution

WB: 1:2000

Function

17094949170949491797456117974561

Molecular Weight

99633 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

IgG2b, k

Subcellular Location

Cytoplasm. Cell membrane. Cell projection, cilium. Golgi apparatus. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane

UniProtKB · P22681

E3 ubiquitin-protein ligase CBL

CBL_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P22681
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CBL
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.3.2.27
Processing: —
Secondary accessions: A3KMP8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Cellular component

Cell membraneCell projectionCytoplasmGolgi apparatusMembrane

Disease

Disease variantProto-oncogene

PTM

PhosphoproteinUbl conjugation

Domain

RepeatZinc-finger

Molecular function

Transferase

Biological process

Ubl conjugation pathway

Related Products

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M00152	Anti-Cbl Monoclonal Antibody
A03693	Anti-Cbl-c Antibody
A00152Y774	Anti-Phospho-Cbl (Y774) Antibody
A00152Y700	Anti-Phospho-Cbl (Y700) Antibody
A00152Y674	Anti-Phospho-Cbl (Y674) Antibody
A00152-1	Anti-c-Cbl (Ab-700) Antibody
P00152-1	Anti-Phospho-CBL (S669) Rabbit Monoclonal Antibody
M03693	Anti-Cbl c (CBLC) Mouse Monoclonal Antibody [Clone ID: OTI4E3]
P00152	Anti-Phospho-CBL (Y774) Rabbit Monoclonal Antibody
P00152-1-carrier-free	Anti-Phospho-CBL (S669) Rabbit Monoclonal Antibody, Carrier-free

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STJ92057	Anti-Cbl antibody
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TMAC-00637-01	Anti-CBL Antibody (8B374)
GWB-668E50	Anti-cbl-c Antibody
MBS8245814-01	Anti-Cbl-3 Antibody
SLM-51640M-01	Mouse Anti-CBL antibody
PB9077	Anti-CBL Antibody Picoband®