Anti-VAMP8 Antibody

• Description:

  Boster Bio Anti-VAMP8 Antibody catalog # A02338. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Vesicle-associated membrane protein 8

• Gene Name:

  VAMP8

• UniProt:

  Q9BV40

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human VAMP8 (NP_003752.2) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Platelets.

• Applications:

  WB

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  WB: 1:500-1:2000

• Form:

  Liquid

• Function:

  SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604) . Also required for dense-granule secretion in platelets (PubMed:12130530) . Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity) . Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity) . Involved in the homotypic fusion of early and late endosomes (By similarity) .

• Molecular Weight:

  11438 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Vesicle-associated membrane protein 8

• Subcellular Location:

  Lysosome membrane

• Protein Name:

  Vesicle-associated membrane protein 8