Anti-CAMKIV CAMK4 Antibody

• Description:

  Boster Bio Anti-CAMKIV CAMK4 Antibody catalog # A01905-1. Tested in WB, ICC, IF, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Calcium/calmodulin-dependent protein kinase type IV; CaMK IV;2.7.11.17; CaM kinase-GR; CAMK4; CAMK, CAMK-GR, CAMKIV;

• Gene Name:

  CAMK4

• UniProt:

  Q16566

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein corresponding to the C-terminus of human CAMKIV.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.

• Applications:

  WB, ICC, IF, IHC, Flow Cytometry

• Purification:

  ProA affinity purified

• Form:

  Liquid

• Function:

  Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4 (+) /CD8 (+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2) . Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs) . Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

• Molecular Weight:

  51926 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Calcium/calmodulin-dependent protein kinase type IV

• Subcellular Location:

  Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity) . .

• Protein Name:

  Calcium/calmodulin-dependent protein kinase type IV