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Anti-eIF5A Antibody

CAT: 0519-A01727-2Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A01727-2Size:100 µL
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Description
Boster Bio Anti-eIF5A Antibody catalog # A01727-2. Tested in WB, ICC, IHC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Eukaryotic translation initiation factor 5A-1; eIF-5A-1; eIF-5A1; Eukaryotic initiation factor 5A isoform 1; eIF-5A; Rev-binding factor; eIF-4D; EIF5A;
Gene Name
EIF5A
UniProt
P63241
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein
Clonality
Polyclonal
Tissue Specificity
Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level) .
Applications
WB, ICC, IHC, IP, Flow Cytometry
Purification
ProA affinity purified
Form
Liquid
Function
MRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
Molecular Weight
16832 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Eukaryotic translation initiation factor 5A-1
Subcellular Location
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Protein Name
Eukaryotic translation initiation factor 5A-1

UniProtKB · P63241

Eukaryotic translation initiation factor 5A-1

IF5A1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P63241
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EIF5A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
eIF-5A-1, eIF-5A1
EC number
—
Processing
—
Secondary accessions
A8K9A0, D3DTP2, P10159, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationHypusine

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndoplasmic reticulumMembraneNucleus

Disease

Disease variant

Molecular function

Elongation factorRNA-binding

Biological process

Protein biosynthesis

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