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Anti-STAT2 Antibody

CAT: 0519-A01360-2Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A01360-2Size:100 µL
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Description
Boster Bio Anti-STAT2 Antibody catalog # A01360-2. Tested in WB, IP applications. This antibody reacts with Human.
Synonyms
Signal transducer and activator of transcription 2; p113; STAT2;
Gene Name
STAT2
UniProt
P52630
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human STAT2.
Clonality
Polyclonal
Applications
WB, IP
Purification
ProA affinity purified
Form
Liquid
Function
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734) . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121) .
Molecular Weight
97916 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Signal transducer and activator of transcription 2
Subcellular Location
Cytoplasm
Protein Name
Signal transducer and activator of transcription 2

UniProtKB · P52630

Signal transducer and activator of transcription 2

STAT2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52630
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STAT2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DLC7, G3V2M6, Q16430, Q16431, Q9UDL4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseHost-virus interactionTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Disease

Disease variant

PTM

PhosphoproteinUbl conjugation

Domain

SH2 domain

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