Anti-SARS Antibody

• Description:

  Boster Bio Anti-SARS Antibody catalog # A00501. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Serine--tRNA ligase, cytoplasmic;6.1.1.11

• Gene Name:

  SARS

• UniProt:

  P49591

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human SARS (NP_006504.2) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Brain.

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Form:

  Liquid

• Function:

  Catalyzes the attachment of serine to tRNA (Ser) in a two-step reaction: serine is first activated by ATP to form Ser- AMP and then transferred to the acceptor end of tRNA (Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339) . Is probably also able to aminoacylate tRNA (Sec) with serine, to form the misacylated tRNA L-seryl-tRNA (Sec), which will be further converted into selenocysteinyl-tRNA (Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339) . In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000) . Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16) . Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000) .

• Molecular Weight:

  58777 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Serine--tRNA ligase, cytoplasmic

• Subcellular Location:

  Cytoplasm

• Protein Name:

  Serine--tRNA ligase, cytoplasmic