Anti-Bcl-2 (phospho-T69) Antibody

• Description:

  Boster Bio Anti-Bcl-2 (phospho-T69) Antibody catalog # A00040T69. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Apoptosis regulator Bcl-2; BCL2;

• Gene Name:

  BCL2

• UniProt:

  P10415

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic phosphopeptide derived from human Bcl-2 around the phosphorylation site of Threonine 69.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in a variety of tissues.

• Applications:

  IHC

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Dilution:

  IHC: 1:50-1:200

• Form:

  Liquid

• Function:

  Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .

• Molecular Weight:

  26266 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Apoptosis regulator Bcl-2

• Subcellular Location:

  Mitochondrion outer membrane

• Protein Name:

  Apoptosis regulator Bcl-2