Mouse T-Cell Differentiation Antigen Cd6, Cd6 Primacu™ ELISA Kit

Mouse T-Cell Differentiation Antigen Cd6, Cd6 Primacu™ ELISA Kit

• Background: T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.
• Description: T-cell differentiation antigen CD6
• Gene Name: Cd6
• Gene ID: 12511
• UniProt: Q61003
• Origin Species: Mouse
• Reactivity: Mouse
• Target: CD6
• Field of Research: Immunology,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 7 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 10.94-700 pg/mL
• Sensitivity: 4.07 pg/mL
• Weight: 72255
• Storage Temperature: 2-8°C