Mouse T-Cell Differentiation Antigen Cd6, Cd6 Primacu™ ELISA Kit

• Background:

  T-cell differentiation antigen CD6, also known as TP12 and CD6, is a single-pass type I membrane protein which contains threeSRCR domains. CD6 / TP12 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP12 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP12 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP12 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

• Description:

  T-cell differentiation antigen CD6

• Gene Name:

  Cd6

• Gene ID:

  12511

• UniProt:

  Q61003

• Origin Species:

  Mouse

• Reactivity:

  Mouse

• Target:

  CD6

• Field of Research:

  Immunology,Stem cells

• Assay Type:

  Sandwich

• Assay Performance Time:

  3.5 Hours

• Standard:

  7 ng/mL

• Sample Type:

  Serum, plasma, cell culture supernates

• Detection Range:

  10.94-700 pg/mL

• Sensitivity:

  4.07 pg/mL

• Weight:

  72255

• Storage Temperature:

  2-8°C