Mouse Interleukin-17A, Il17a Primacu™ ELISA Kit

Mouse Interleukin-17A, Il17a Primacu™ ELISA Kit

• Background: IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
• Description: Interleukin-17A
• Synonyms: Ctla8;Il17
• Gene Name: Il17a
• Gene ID: 16171
• UniProt: Q62386
• Origin Species: Mouse
• Reactivity: Mouse
• Target: IL17
• Field of Research: Neuroscience,Immunology,Cancer
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 10 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 15.63-1000 pg/mL
• Sensitivity: 3.33 pg/mL
• Weight: 17490
• Storage Temperature: 2-8°C