Human Interleukin-17A, IL17A Primacu™ ELISA Kit

Human Interleukin-17A, IL17A Primacu™ ELISA Kit

• Background: IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
• Description: Interleukin-17A
• Synonyms: CTLA8;IL17
• Gene Name: IL17A
• Gene ID: 3605
• UniProt: Q16552
• Origin Species: Human
• Reactivity: Human
• Target: IL17
• Field of Research: Immunology,Neuroscience,Cancer
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 0.75 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 1.17-75 pg/mL
• Sensitivity: 0.29 pg/mL
• Weight: 17504
• Storage Temperature: 2-8°C