Mouse Interleukin-6 Receptor Subunit Alpha, Il6ra Primacu™ ELISA Kit

• Background:

  Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy

• Description:

  Interleukin-6 receptor subunit alpha

• Synonyms:

  Il6r

• Gene Name:

  Il6ra

• Gene ID:

  16194

• UniProt:

  P22272

• Origin Species:

  Mouse

• Reactivity:

  Mouse

• Target:

  IL-6R

• Field of Research:

  Neuroscience,Immunology,Stem cells

• Assay Type:

  Sandwich

• Assay Performance Time:

  3.5 Hours

• Standard:

  4 ng/mL

• Sample Type:

  Serum, plasma, cell culture supernates

• Detection Range:

  6.25-400 pg/mL

• Sensitivity:

  1.15 pg/mL

• Weight:

  50455

• Storage Temperature:

  2-8°C