Mouse Interleukin-6 Receptor Subunit Beta, Il6st Primacu™ ELISA Kit

• Background:

  Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

• Description:

  Interleukin-6 receptor subunit beta

• Gene Name:

  Il6st

• Gene ID:

  16195

• UniProt:

  Q00560

• Origin Species:

  Mouse

• Reactivity:

  Mouse

• Target:

  gp130

• Field of Research:

  Cancer,Cell biology,Immunology,Cardiovascular,Epigenetics and nuclear signaling

• Assay Type:

  Sandwich

• Assay Performance Time:

  3.5 Hours

• Standard:

  7.5 ng/mL

• Sample Type:

  Serum, plasma, cell culture supernates

• Detection Range:

  11.72-750 pg/mL

• Sensitivity:

  2.7 pg/mL

• Weight:

  102451

• Storage Temperature:

  2-8°C