Human Fractalkine, CX3CL1 Primacu™ ELISA Kit

Human Fractalkine, CX3CL1 Primacu™ ELISA Kit

• Background: Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
• Description: Fractalkine
• Synonyms: FKN;NTT;SCYD1
• Gene Name: CX3CL1
• Gene ID: 6376
• UniProt: P78423
• Origin Species: Human
• Reactivity: Human
• Target: Fractalkine
• Field of Research: Neuroscience,Cardiovascular,Immunology,Stem cells
• Assay Type: Sandwich
• Assay Performance Time: 3.5 Hours
• Standard: 6 ng/mL
• Sample Type: Serum, plasma, cell culture supernates
• Detection Range: 9.38-600 pg/mL
• Sensitivity: 3.81 pg/mL
• Weight: 42203
• Storage Temperature: 2-8°C