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IHSP110-33

CAT: 0804-HY-161765-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161765-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IHSP110-33 is an inhibitor for heat shock protein 110 (HSP110). iHSP110-33 exhibits antitumor efficacy agaisnt large B-cell lymphoma and classical Hodgkin lymphoma. iHSP110-33 shows a synergistic effect with Selinexor , inhibits the STAT6 phosphorylation, and enhances its antitumor activity.[1].
UNSPSC
12352005
Target
HSP; STAT
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ihsp110-33.html
Purity
99.59
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
COC1=CC(C2=CC(/C=C/C3=CC=CC=C3)=C(C4=CC(C)=C(C5=CC=C(OC)C(OC)=C5)N=C4)N=C2)=CC(OC)=C1OC
Molecular Formula
C36H34N2O5
Molecular Weight
574.67
References & Citations
[1]Durand M, et al., A first-in-class inhibitor of HSP110 to potentiate XPO1-targeted therapy in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma. J Exp Clin Cancer Res. 2024 May 22;43 (1) :148.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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