mEH-IN-1

mEH-IN-1

• CAS Number: 2418576-06-2
• UNSPSC Description: mEH-IN-1 (Compound 62) is a potent microsomal epoxide hydrolase (mEH) inhibitor with the IC50 of 2.2 nM. The mEH is a mammalian α/β-fold hydrolase enzyme, expressed in almost all tissues, hydrolyzes a wide range of epoxide containing molecules. The mEH is mainly localized in the endoplasmic reticulum (ER) of eukaryotic cells. mEH-IN-1 can be used for the research of preeclampsia, hypercholanemia and cancer[1].
• Target Antigen: Epoxide Hydrolase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Neurological Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/meh-in-1.html
• Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: NC(C(C1CCCC1)SCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O
• Molecular Weight: 385.37
• References & Citations: [1]Bogdan Barnych, et al. Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem. 2020 May 1;193:112206.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported