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DTME

CAT: 0804-HY-W106411-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W106411-01Size:5 mg
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Description
DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT. DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions[1].
CAS Number
71865-37-7
Product Name Alternative
Dithio-bis-maleimidoethane
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dtme.html
Concentration
10mM
Purity
99.03
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C=C1)N(CCSSCCN2C(C=CC2=O)=O)C1=O
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.36
Precautions
H302+H312+H332, H315, H319, H335
References & Citations
[1]Kovalenko OV, et al. Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. Biochem J. 2004 Jan 15;377 (Pt 2) :407-17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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